Isolation of Glucosylceramides from Yeast (Hansenula ciferri)

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Long chain base-acetyl coenzyme A acetyltransferase from the microsomes of Hansenula ciferri. I. Isolation and properties.

Microsomes of the yeast, Hansenula ciferri NRRL Y-1031, F-60-10, contain an enzyme (long chain base-acetyl coenzyme A acetyltransferase, EC 2.3 . 1) which catalyzes the transfer of the acetyl moiety of acetyl coenzyme A to both the amino and hydroxyl groups of the sphingosine bases; a separation of these two transfer reactions could not be achieved. The enzyme also catalyzed an acetyl transfer ...

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Long Chain Base-Acetyl Coenzyme A Acetyltransferase from the Microsomes of Hansenula ciferri

Microsomes of the yeast, Hansenula ciferri NRRL Y-1031, F-60-10, contain an enzyme (long chain base-acetyl coenzyme A acetyltransferase, EC 2.3 . 1) which catalyzes the transfer of the acetyl moiety of acetyl coenzyme A to both the amino and hydroxyl groups of the sphingosine bases; a separation of these two transfer reactions could not be achieved. The enzyme also catalyzed an acetyl transfer ...

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Long Chain Base-Acetyl Coenzyme A Acetyltransferase from the Microsomes of Hansenula ciferri

The microsomal long chain base-acetyl coenzyme A acetyltransferase (BAREHHOLZ, Y., AND GATT, S. (1969) Biochem. Biophys. Res. Commun. 35, 676; (1972) J. Biol. Chem. 247, 6827) catalyzes a bisubstrate reaction in which the acetyl group of acetyl-CoA is transferred to free or N-acetylated sphingosine bases and to long chain primary amines. In this reaction the acetyl-CoA is present in a true, mol...

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Long Chain Base-Acetyl Coenzyme A Acetyltransferase from the Microsomes of Hansenula ciferri

Microsomes of the yeast, Hansenula ciferri NRRL Y-1031, F-60-10, contain an enzyme (long chain base-acetyl coenzyme A acetyltransferase, EC 2.3 . 1) which catalyzes the transfer of the acetyl moiety of acetyl coenzyme A to both the amino and hydroxyl groups of the sphingosine bases; a separation of these two transfer reactions could not be achieved. The enzyme also catalyzed an acetyl transfer ...

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The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri.

Studies of the biosynthesis of sphingosine and dihydrosphingosine in whole animals'-4 and in brain tissue homogenates5-8 indicate that the first two carbon atoms of these compounds are derived from serine while the remainder of the molecule is derived from palmitic acid or palmitaldehyde. Brady, Formica, and Koval6 reported that pyridoxal phosphate (PLP), Mn++, nicotinamide, cytidine 5'-diphosp...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1971

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)62080-0